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How to Take Source Naturals Progesterone Cream: Side Effects, Dosage

Learn about Source Naturals Progesterone Cream dosage, side effects, warnings, and cost. Educational information for informed conversations with your provider.

Not medical advice. Speak with a healthcare professional before using any medication.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Reviewed by:

Hazar Metayer

PharmD

LinkedIn

Updated Feb, 15

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Information sourced from manufacturer labeling and publicly available references including NIH Office of Dietary Supplements.

Disclaimer: This content is for informational purposes only and is not medical advice. Voshell's Pharmacy does not diagnose conditions or determine treatment plans. Patients should consult their licensed prescriber regarding therapy decisions. Compounded medications are not FDA-approved and prepared only pursuant to a valid prescription.
Disclosure: Voshell's Pharmacy is a licensed compounding pharmacy that prepares and sells compounded hormone replacement therapy by prescription. As a provider of products in related categories, our perspective may be influenced by our professional and commercial interests. This content reflects our review of publicly available scientific literature and does not constitute medical advice. Compounded medications are not FDA-approved.

How to Take Source Naturals Progesterone Cream

Disclosure: Voshell's Pharmacy is a licensed compounding pharmacy that prepares and sells compounded hormone therapy by prescription. As a provider of products in the hormone health space, our perspective may be influenced by our professional and commercial interests. All brand names and trademarks are the property of their respective owners.

 

How to Take Source Naturals Progesterone Cream

 

The following dosing information reflects Source Naturals Progesterone Cream product labeling:

  • Serving size: According to Source Naturals Progesterone Cream product labeling, the product contains approximately 20 mg of progesterone per 1/4 teaspoon; consult your healthcare provider for personalized dosing guidance.
  • Application sites: According to Source Naturals Progesterone Cream product labeling, apply to soft-skinned areas such as the inner arms, inner thighs, or abdomen, and rotate application sites.
  • How to apply: According to Source Naturals Progesterone Cream product labeling, massage the measured amount into clean, dry skin until fully absorbed.
  • Application schedule: Per the manufacturer's labeling, consult your healthcare provider about the appropriate application schedule for your individual needs, as dosing may vary by cycle status.
  • Consistent use: According to Source Naturals Progesterone Cream product labeling, this supplement is intended for regular use as directed on the label.

According to Source Naturals Progesterone Cream product labeling, do not exceed the recommended serving. Consult your healthcare provider before use, particularly if you take prescription hormones or have an underlying health condition.

 

Warnings Before Using Source Naturals Progesterone Cream

 

According to Source Naturals Progesterone Cream product labeling, avoid use if you have a history of breast cancer, unexplained vaginal bleeding, or active liver disease. According to Source Naturals Progesterone Cream product labeling, consult your healthcare provider before use if you are on prescription hormone replacement therapy. According to Source Naturals Progesterone Cream product labeling, stop use and consult a healthcare provider if you notice new breast tenderness, significant mood changes, or persistent headaches. According to Source Naturals Progesterone Cream product labeling, consult your healthcare provider before use if you take fertility medications or thyroid treatment.

Source Naturals Progesterone Cream Side Effects

Very common

Mild

Breast Tenderness — Labeled Warning

According to Source Naturals Progesterone Cream product labeling, breast soreness or fullness is a labeled warning for this product. Stop use and consult a healthcare provider if breast tenderness is persistent or severe. If symptoms persist or worsen, stop use and consult a healthcare provider.

Normally lasts for:

4–12 hours

Occasional

Mild

Headaches

According to Source Naturals Progesterone Cream product labeling, some users may experience mild headaches when beginning use of this product. If symptoms persist or worsen, stop use and consult a healthcare provider.

Normally lasts for:

2–6 hours

Common

Mild

Fatigue or Sleepiness

According to Source Naturals Progesterone Cream product labeling, some users may notice increased tiredness or drowsiness, particularly after application. If symptoms persist or worsen, stop use and consult a healthcare provider.

Normally lasts for:

3–8 hours

Uncommon

Mild

Mood Changes

According to Source Naturals Progesterone Cream product labeling, some users may notice mood shifts such as irritability during initial use. If symptoms persist or worsen, stop use and consult a healthcare provider.

Normally lasts for:

2–10 hours

Occasional

Mild

Skin Irritation at Application Site

According to Source Naturals Progesterone Cream product labeling, some users may experience redness or itching at the application site. Rotating application areas may help reduce this effect. If symptoms persist or worsen, stop use and consult a healthcare provider.

Normally lasts for:

1–4 hours

Uncommon

Moderate

Spotting or Cycle Changes

According to Source Naturals Progesterone Cream product labeling, spotting or changes in menstrual timing may occur, particularly in perimenopause. Stop use and consult a healthcare provider if bleeding becomes heavy or persistent. If symptoms persist or worsen, stop use and consult a healthcare provider.

Normally lasts for:

24–72 hours

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Questions about Source Naturals Progesterone Cream? Talk with your healthcare provider.

If you have questions about this dietary supplement, speak with your healthcare provider or pharmacist for guidance based on your individual health needs.

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What If You Forgot to Take Source Naturals Progesterone Cream

 

What If You Forgot to Apply Source Naturals Progesterone Cream?

 

If you miss a dose, apply when you remember — and if it is already close to your next scheduled application, skip the missed dose. According to Source Naturals Progesterone Cream product labeling, do not apply extra cream to make up for a missed dose.

Simply resume your usual routine the next day. Refer to the manufacturer's labeling for dosing guidance specific to this product.

What if You Took Too Much Source Naturals Progesterone Cream

 

What if You Applied Too Much Source Naturals Progesterone Cream?

 

If more than the recommended amount was applied, contact Poison Control at 1-800-222-1222. If a child has been exposed to this product, seek urgent medical care immediately.

  • Do not take additional doses until you have spoken with Poison Control or a healthcare provider.
  • Do not apply additional doses until you have spoken with Poison Control or a healthcare provider.
  • If symptoms such as unusual drowsiness, breast discomfort, or mood changes occur, seek medical attention.
  • Keep this and all supplements out of reach of children.

How Much Does Source Naturals Progesterone Cream Cost

 

Cost of Source Naturals Progesterone Cream

 

Source Naturals Progesterone Cream is an over-the-counter product, so insurance generally does not cover it.

These are approximate examples only and actual prices will vary by retailer, location, and time of purchase. According to retailer listings reviewed in early 2026, approximate price ranges included:

  • $10–20 for a standard 4 oz jar (2% progesterone)
  • $20–30 for larger or specialty versions depending on the retailer

Occasional coupons or store promotions may reduce the cost. These figures are approximate and may no longer reflect current pricing.

About compounded medications: Compounded medications are not FDA-approved. They have not been reviewed by the FDA for safety, effectiveness, or quality. FDA-approved medications should be considered first when commercially available options meet patient needs. Compounded preparations are prepared by licensed pharmacists in response to valid prescriptions for individual patients with specific medical needs.

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