What to Know About EstroVital Support

DISCLOSURE: Voshell's Pharmacy is a licensed compounding pharmacy that prepares and sells compounded medications by prescription. As a provider of competing products, our perspective may be influenced by our professional and commercial interests.

EstroVital Support is the name Voshell's Pharmacy uses for compounded preparations that may include soy isoflavones, red clover isoflavones, black cohosh, DIM, calcium-D-glucarate, vitamin D3, vitamin B6, and magnesium, prepared in response to a valid prescription from a qualified prescriber. Compounded medications are not reviewed by FDA for safety or effectiveness before dispensing and are prepared by a licensed pharmacist only in response to a valid prescription for an individual patient. This preparation is not prescription hormone therapy. A qualified prescriber should be consulted to determine whether this preparation is appropriate for an individual patient.

How These Ingredients Have Been Studied

• Phytoestrogens: According to the NIH Office of Dietary Supplements, soy isoflavones and red clover isoflavones are plant-derived compounds that have been studied for their weak binding activity at estrogen receptors. Inclusion of these ingredients in a compounded preparation does not establish clinical benefit for any disease, condition, or patient outcome.
• DIM and calcium-D-glucarate: According to the NIH Office of Dietary Supplements, diindolylmethane (DIM) and calcium-D-glucarate are involved in phase II detoxification pathways and have been studied for roles in estrogen metabolite processing. Inclusion of these ingredients in a compounded preparation does not establish clinical benefit for any disease, condition, or patient outcome.
• Black cohosh and supportive nutrients: According to NAMS (the North American Menopause Society), black cohosh has been studied for its potential role in vasomotor symptom research during menopause. According to the NIH Office of Dietary Supplements, vitamin D3, B6, and magnesium play a role in bone metabolism and nervous system function. Inclusion of these ingredients in a compounded preparation does not establish clinical benefit for any disease, condition, or patient outcome.

Safety and Practical Considerations

• Contraindications: Use with caution or avoid if you have a history of estrogen-sensitive cancer, active clotting disorders, or are pregnant or breastfeeding — consult a qualified prescriber before use.
• Interactions and tolerability: Ingredients in this preparation may affect drugs metabolized by hepatic enzymes; mild gastrointestinal discomfort or headaches have been reported in published literature. A qualified prescriber should review your full medication list.
• FDA boxed warnings: According to the FDA-approved prescribing information for systemic estrogens, products in this class carry boxed warnings regarding endometrial cancer (in unopposed-estrogen use), cardiovascular events (stroke, deep vein thrombosis, pulmonary embolism), breast cancer, and probable dementia in postmenopausal women age 65 and older. Compounded preparations are not reviewed by FDA, but the same labeled risks for the underlying hormones apply.
• Compounded options: When a tailored dose or combination of ingredients is needed, a compounding pharmacist may prepare a formulation only upon receipt of a valid prescription from a qualified prescriber.

Compounded hormone preparations are not reviewed by FDA for safety or effectiveness before dispensing. They are prepared by a licensed pharmacist only in response to a valid prescription for an individual patient. Commercially available hormone therapy options should be considered first when they meet patient needs. Clinical decisions about hormone therapy should be made with a qualified prescriber.